May there always be such a pain in my heart, day and night, that cannot be reduced by medicine nor soothed by prayer.

Here, the lover does not ask for relief, but prays for an incurable ache of longing that stays in the heart through every passing hour. In the poetic tradition, the pain of love is never treated as a disease; it is cherished as a sacred companion that gives life its deepest depth. By wishing away both worldly medicine and divine healing, the poet embraces this sweet anguish as something far more valuable than peace itself.