From the gatherings of the Sheikh and the Brahmin, even from Meera, you must depart; from the Kaaba and the monastery, you must also depart.

This profound couplet suggests a radical detachment. Mir Taqi Mir is advising the listener to abandon not just the physical comfort of sacred places like the Kaaba and Dair, but also the company of religious scholars (Shaikh and Brahman). It speaks to a spiritual journey that demands leaving behind all worldly attachments and conventional comforts to find true truth.