The affection that was initially beneficial to the temperament, in the end, those very medicines caused us harm.

This powerful couplet speaks to the deepest irony of heartbreak. Mir Taqi Mir suggests that the very things—the supposed remedies, the comfort, or the affections—that were meant to soothe his emotional wounds at the beginning, were ultimately the source of his greatest pain. It's the pain of misplaced trust, where the cure is far more devastating than the initial illness.