All efforts towards good learning are in vain, because we are foes of reason and truth.

This couplet suggests that all the efforts put into providing good education and knowledge become pointless when people deliberately choose to reject intellect and truth. It highlights the futility of teaching those who are fundamentally opposed to reason and facts. Essentially, if someone is determined to be an 'enemy' of wisdom and reality, then even the most excellent education will fail to enlighten them. It's a powerful statement about how crucial an open mind is for learning, and how a closed mind renders all educational endeavors useless.